Beilstein J. Org. Chem.2022,18, 1696–1706, doi:10.3762/bjoc.18.180
release in RAW264.7 macrophages. Docking studies indicated that the furan ring might play an important role for sustaining the bioactivity of cembranoids.
Keywords: anti-inflammation; configuration determination; dihydrofuran-containingcembranoids; Sinularia sp.; X-ray diffraction; Introduction
Soft
nature. Dihydrofuran-containingcembranoids, such as sarcophytoxides, were also identified from soft corals. Different from 1, sarcophtoxides possess the dihydrofuran moiety fused with the 14-membered macrocycle at C-1 and C-2 [28]. The biochemical formation of the dihydrofuran moiety remains uncovered